1. Introduction and Basics | 2. Safety and Side Effects | 3. Usage and Dosage | 4. Combination and Interactions | 5. Effectiveness and Results | 6. Special Considerations | 7. Monitoring and Follow-up | 8. Prescription and Availability | 9. Missed Dose and Management | 10. Lifestyle and Recommendations
1. Introduction and Basics ↑
What is Semaglutide?
Semaglutide is a prescription medication that is used to help people with obesity lose weight. Semaglutide is marketed as a weight loss medication under the brand names Ozempic®, Wegovy®, and Rybelsus®
Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists, or GLP-1 RAs. It mimics the GLP-1 hormone, released in the gut in response to eating.
One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood sugar (glucose). For that reason, health care providers have used Semaglutide for more than 15 years to treat Type 2 diabetes.
GLP-1 in higher amounts also interacts with the parts of the brain that suppress your appetite and signal you to feel full. When used in conjunction with diet and exercise, it can cause significant weight loss and a reduced risk of cancer, diabetes, and heart disease in people who are obese or overweight.
How does Semaglutide work?
Semaglutide is used along with a diet and exercise program to control blood sugar levels in adults with type 2 diabetes.
It mimics the GLP-1 hormone, released in the gut in response to eating. One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood sugar (glucose).
How does Semaglutide help with weight loss?
Semaglutide replicates the effects of a hormone that controls how the brain processes appetite and insulin production. Hence, why it is categorized as glucagon-like peptide-1 receptor agonist (GLP-1 RA). With these benefits, it aids in the weight management of those with obesity or type 2 diabetes when combined with sufficient healthier lifestyle changes. Weight loss results will improve with a consistent weight management routine.
As a GLP-1 RA, Semaglutide suppresses appetite and increases insulin production. Not only does this help the benefits and consistency of a low-calorie, low-fat, and low-carb diet and regular physical activity, but it also decreases the risk of near-fatal conditions like a stroke, heart attack, and other disease by regulating blood sugar level and blood pressure in those affected by obesity and / or type 2 diabetes.
Semaglutide achieves these benefits by modifying the hypothalamus, the control center of the brain, that handles the body's temperature, mood, and blood pressure. By toning down appetite and blood sugar level, a patient undergoing Semaglutide treatments can have an easier time adjusting to a different and healthier diet instead of cravings for foods that perpetuate and increase the condition of obesity.
Semaglutide can even indirectly slow digestion as some research indicates that patients who take Semaglutide have food remain longer in the stomach compared to people who don't. This also helps patients maintain a feeling of fullness that leads to better control of caloric intake for weight management.
Does Semaglutide get rid of belly fat?
Yes. Semaglutide improves body composition by helping patients lose weight and reduce excess fat, including stubborn belly fat. It also increases the proportion of lean body mass. In general, the more weight a patient loses with Semaglutide, the greater the improvements he / she will see in overall body composition across all areas.
What is the protocol for Semaglutide?
Adults 18 years of age and older start treatment with 0.25 milligrams (mg) injected under the skin (subcutaneously) once a week for 4 weeks. The dosage for weeks 5-8 may increase to .50 mg once per week. Dosage after week 8 may increase no more than .50 mg per week. Dosage is not to exceed 2.4 mg once per week. The licensed medical professional will determine the dosage based on effectiveness and tolerance to the medication.
What is the difference between Ozempic®, Wegovy®, Rybelsus®, and Semaglutide?
Ozempic®, Wegovy®, Rybelsus®, and Semaglutide are all the same medication. Semaglutide is the generic name for the branded diabetes medication Ozempic®. Semaglutide branded under the names Wegovy® and Rybelsus® are sold and utilized as weight loss medications. Although dosage and protocol may vary slightly Ozempic®, Wegovy® and Semaglutide are all the same subcutaneous injectable medication. Rybelsus® is an oral tablet form of Semaglutide.
Semaglutide was initially developed to treat Type 2 diabetes in adults and marketed under the brand name Ozempic®. Used along with diet and exercise, the drug improves glycemic control in adults with Type 2 diabetes which can help with weight loss.
Can a patient keep the weight off after Semaglutide treatment ends?
Yes. Weight loss results can be retained by most patients with healthy lifestyle changes, but many do regain weight. Researchers have found that people who lost the most weight while taking Semaglutide tended to then regain the most after stopping it, although they still retained a larger reduction from baseline than participants who had lost less weight during the treatment period. Maintaining a healthy lifestyle which includes better eating habits, regular exercise, reduced stress, and quality sleep after Semaglutide treatment has been terminated will assist in keeping any unwanted weight from returning.
Does Semaglutide curve appetite?
Yes. Semaglutide lowers body weight by reducing appetite and hunger, increasing satiety, reducing food cravings, altering food preferences, and reducing energy intake.
What are the NICE guidelines for Semaglutide?
The National Institute For Health And Care Excellence (NICE) guidelines for using Semaglutide to treat weight loss includes people with a BMI of 30 kg/m² or more (obesity), or a BMI from 27 kg/m² to less than 30 kg/m² (overweight) and at least 1 weight-related comorbidity.
Is Semaglutide just an appetite suppressant?
No. Semaglutide lowers blood sugar, suppresses appetite, and gives the patient a feeling of fullness in the stomach. For these reasons it can be a very effective weight loss medication. Semaglutide works to suppress appetite by mimicking the hormone glucagon-like peptide-1 (GLP-1), which is released after eating. It is injected once weekly on the same day each week.
2. Safety and Side Effects ↑
What are the eligibility requirements of Semaglutide?
- Must be 18 years of age or older to receive Semaglutide Injections.
- Any patient with known allergies to Semaglutide is not eligible to receive Semaglutide Injections.
- Any patient taking a medication that has a negative effect when combined with Semaglutide is not eligible for Semaglutide Injections.
- Any patient with a history of negative reactions to injections is not eligible to receive Semaglutide Injections.
- Patients must have a body mass index (BMI) of 30 or greater or 27-29 and at least one weight-related condition, such as high blood pressure, Type 2 Diabetes, or high cholesterol to be eligible for Semaglutide Injections.
- Patients with a medical history of Medullary Thyroid Cancer, Pancreatic Cancer, Multiple Endocrine Neoplasia Syndrome Type 2 (MEN2), Diabetic Retinopathy, Severe Depression, Gallbladder Disease, Type I Diabetes (insulin dependent) are not eligible to receive Semaglutide Injections.
- Patients on certain medications may not be eligible to receive Semaglutide Injections due to possible negative drug interactions. Insulin, Sulfonylureas, and Glinides as well as other oral medications may pose a higher risk of drug interaction potentially resulting in Hypoglycemia (low blood sugar) or other serious negative adverse effects. The PWLC telemedicine partner's treating licensed medical professional should review all medications being taken by the patient to determine eligibility for Semaglutide Injections.
- Patients that are currently pregnant or breast-feeding, experiencing current drug or alcohol addiction, experiencing Anorexia or Bulimia, experiencing Overt Psychosis are not eligible to receive Semaglutide Injections.
- Patients must be approved by the PWLC telemedicine partner's licensed medical professionals to receive Semaglutide Injections.
- Any patient receiving Semaglutide Injections is highly recommended to follow a Physicians WEIGHT LOSS Centers® weight loss program and must maintain an active PWLC.com membership to qualify for prescription weight loss medications.
Who may be eligible with approval from the PWLC telemedicine partner's treating licensed medical professional?
- Patients with a history of Ulcer Disease (non-active).
- Patients who are HIV positive or have AIDS must have approval from the PWLC telemedicine partner's treating licensed medical professional.
- Any patient taking medications that have are known to cause injection site irritation or increased bleeding are required to take extra precautions when receiving Semaglutide Injections. This includes extra post injection pressure on the injection wound and sitting for 15 minutes post injection for observation.
Is Semaglutide safe?
Yes. Semaglutide treatments have been researched and proven to be effective and safe across a wide spectrum of patients with obesity who might be prescribed this drug, whether the patient is older or younger, higher BMI or lower, and regardless of race/ethnicity. Semaglutide like most medications does have possible side effects and contraindications and may not be right for all patients.
What are the common side effects of Semaglutide?
- nausea
- vomiting
- diarrhea
- abdominal pain
- constipation
- heartburn
- burping
Who should not take Semaglutide?
- Anyone under 18 years of age is not eligible to receive Semaglutide Injections.
- Any patient with known allergies to Semaglutide is not eligible to receive Semaglutide Injections.
- Any patient taking a medication that has a negative effect when combined with Semaglutide is not eligible for Semaglutide Injections.
- Any patient with a history of negative reactions to injections is not eligible to receive Semaglutide Injections.
- Patients must have a body mass index (BMI) of 30 or greater or 27-29 and at least one weight-related condition, such as high blood pressure, Type 2 Diabetes, or high cholesterol to be eligible for Semaglutide Injections.
- Patients with a medical history of Medullary Thyroid Cancer, Pancreatic Cancer, Multiple Endocrine Neoplasia Syndrome Type 2 (MEN2), Diabetic Retinopathy, Severe Depression, Gallbladder Disease, Type I Diabetes (insulin dependent) are not eligible to receive Semaglutide Injections.
- Patients on certain medications may not be eligible to receive Semaglutide Injections due to possible negative drug interactions. Insulin, Sulfonylureas, and Glinides as well as other oral medications may pose a higher risk of drug interaction potentially resulting in Hypoglycemia (low blood sugar) or other serious negative adverse effects. The PWLC telemedicine partner's treating licensed medical professional should review all medications being taken by the patient to determine eligibility for Semaglutide Injections.
- Patients that are currently pregnant or breast-feeding, experiencing current drug or alcohol addiction, experiencing Anorexia or Bulimia, experiencing Overt Psychosis are not eligible to receive Semaglutide Injections.
Can Semaglutide damage the pancreas?
Yes. Although rare, pancreatitis has been reported as a potential side effect of Semaglutide treatment. Pancreatitis is serious and can be life-threatening. The patient should seek immediate medical attention if he / she develops severe abdominal pain, experiences nausea, vomiting, and / or jaundice (yellowing of skin and eyes). Always contact the treating physician if any symptoms or side effects occur.
What are the box warnings for Semaglutide?
The box warnings for Semaglutide is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).Can too much Semaglutide be injected at one time?
Yes. A patient self-injecting Semaglutide should pay careful attention not to administer more than the prescribed dosage. A patient may develop severe hypoglycemia (low blood sugar) if too much Semaglutide is injected at one time. In the event of an overdose, the patient should seek immediate medical attention and monitor for signs and symptoms of low blood sugar using a glucometer. If any adverse symptoms occur the patient should contact emergency services as well as contact the treating licensed medical professional..
Can a patient drink alcohol while being treated with Semaglutide?
Yes, but it is not advised. Patients are discouraged from consuming any alcohol while on a weight loss program.
If the patient's blood sugar is under control while taking Semaglutide, an occasional drink should be fine. Experts recommend no more than one drink for females and two drinks for males. Having more drinks can possibly cause hypoglycemia (low blood sugar).
If a patient wishes to have an occasional alcoholic drink while being treated with Semaglutide, it's a good idea for he / she to discuss it with the treating licensed medical professional prior to consuming any alcohol.
A patient being treated with Semaglutide should make sure he / she only drinks a moderate amount of alcohol. Drinking a moderate amount of alcohol typically does not cause hypoglycemia. A moderate amount is one drink for females and two drinks for males. One drink is eight ounces of wine, a 12-ounce beer, or one and a half ounces of 80-proof spirits. Keeping alcohol limited to these amounts may help the patient stay safe.
If a patient chooses to consume alcohol while being treated with Semaglutide he / she should eat while drinking. Consuming alcohol on an empty stomach is more likely to cause hypoglycemia. Eating food while consuming alcohol, especially protein, helps slow digestion and may keep the patient's blood sugar in a healthy range. Eating foods with high amounts of sugar should be avoided as these can cause a rise in blood sugar.
It is a good idea to for the patient to let friends and family know about his / her Semaglutide treatments and to make sure they know the signs of hypoglycemia, which may include: dizziness, rapid heart rate, shortness of breath, chills, sweats, tremors, slurring of speech or even passing out. This is so they can be aware of any potential risks and help if the patient's blood sugar gets too low. If the patient were to pass out, those who are with him / her need to know this is a medical emergency and get the appropriate medical help.
Does Semaglutide make a patient lose muscle?
Yes. Research has shown that muscle mass loss can be a side effect of Semaglutide. This is not unique to the drug as other GLP-1 agonist drugs can have the same side effect.
Increased protein consumption and strength training are recommended to help prevent muscle mass loss while being treated with Semaglutide and other GLP-1 agonist drugs.Does Semaglutide go bad if not refrigerated?
Yes. Semaglutide will break down quickly if not kept refrigerated. Semaglutide will be shipped in refrigerated packaging. Semaglutide should remain refrigerated (between 36°F to 46°F or 2°C to 8°C) and last about 28 days from the time the medication seal is broken, and it is first used.
Are there any long-term side effects of Semaglutide?
Maybe. Semaglutide injections may increase the risk that a patient will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer). Laboratory animals who were given Semaglutide developed tumors, but it is not known if this medication increases the risk of tumors in humans.
Can Semaglutide cause hair thinning?
Maybe. Hair loss is not listed as a potential side effect of Semaglutide, but in clinical trials for Wegovy® (Semaglutide),
3% of people reported hair loss, compared to 1% of people who received a placebo.Is Semaglutide hard on the liver?
No. There have been no published case reports of hepatotoxicity due to Semaglutide and the product label does not list liver damage as an adverse event. Liver injury due to Semaglutide would be rare if it occurred at all.
What happens if Semaglutide gets warm?
Heat and moisture will destroy the enzymes in Semaglutide, breaking down the medication.
This can cause the medication to be ineffective. Keep Semaglutide refrigerated (between 36°F to 46°F or 2°C to 8°C).
Can Semaglutide cause fatigue?
Yes. Some patients taking Semaglutide in conjunction with other medications may experience mild to severe hypoglycemia, or low blood sugar, which may cause the patient to feel fatigued. Hypoglycemia symptoms include drowsiness, restless sleep, shakiness, feeling weak, and tiredness. Hyperglycemia, or high blood sugar, may also cause drowsiness. The patient should seek immediate medical attention and contact the treating licensed medical professional if any symptoms of hypoglycemia or hyperglycemia occur. The patient should discuss all prescribed and over-the-counter medications as well as any supplements he / she is taking with the treating licensed medical professional to avoid and or reduce the risk of drug interactions with Semaglutide.
What happens if a patient does not eat while being treated with Semaglutide?
Hypoglycemia, low blood sugar, may occur if a patient does not eat while being treated with Semaglutide. Other serious side effects that may also occur include nausea, vomiting, fatigue, feeling weak, and tired. The patient should seek immediate medical attention and contact the treating licensed medical professional if any of these symptoms occur. Patients being treated with Semaglutide for weight loss should eat regularly to avoid potential side effects. A diet higher in protein limiting greasy foods, refined carbohydrates, and sweet desserts is recommended.
Does Semaglutide shrink the stomach?
No. Semaglutide treatment for weight loss does not actually shrink the stomach. Semaglutide works in the body by regulating blood sugar, suppressing appetite, and making the patient feel full.
What should I do if I experience severe side effects while taking Semaglutide?
If you experience any severe side effects contact your physician immediately or get emergency medical treatment.
3. Usage and Dosage ↑
How long does a patient stay on Semaglutide for weight loss?
The FDA recommends incorporating Semaglutide into a weight loss program of
16 to 20 weeks to see maximum weight loss benefits and other health advantages. The dosage of Semaglutide medication should start at .25 mg once per week and gradually increase to no more than 2.4 mg once per week to be effective. This can also help to reduce the impact of common side effects like gastrointestinal disorders.
Why does Semaglutide dosage start so low?
Semaglutide is given in short doses first
to avoid the severity and frequency of common side effects like nausea, diarrhea, and vomiting. However, even with a once a week 0.25 mg dose, some patients report to feeling the effects as Semaglutide can lower blood sugar level immediately, which can be impactful for those with type 2 diabetes and have not yet found a consistent diabetes medication.
Why is Semaglutide dosage increased?
Semaglutide dosage is slowly increased from .25 mg once per week to as high as 2.4 mg once per week to assist with the tolerance of the medication and to help reduce the risk of side effects. The FDA recommends that the dosage of Semaglutide should be increased to as much as 2.4 mg once per week to maximize weight loss benefits as well as other health benefits and to reduce the impact of common side effects like gastrointestinal disorders.
Can Semaglutide be taken indefinitely?
Yes. Some patients may be able to take Semaglutide indefinitely. Patients with type 2 diabetes who use Semaglutide for glycemic control to manage their symptoms and blood sugar level may be approved by the treating licensed medical professional to use Semaglutide for an extended period of time.
Is it better to take Semaglutide at night or in the morning?
Semaglutide injections can be administered day or night with no distinction in effectiveness. Semaglutide injections should be administered on the same day each week, at any time of the day, with or without meals.
The oral tablet form of Semaglutide currently sold under the brand name Rybelsus® should be taken in the morning 30 minutes before the first meal of the day.
Where is the best part of the body to inject Semaglutide for weight loss?
Semaglutide should be injected under the skin (subcutaneously) of the stomach, thigh, or upper arm. The patient may choose which injection site he / she prefers. The patient may choose to utilize the same injection site or rotate the injection site. Semaglutide is a once-weekly injection and should be administered on the same day each week.
How many weeks can a patient take Semaglutide?
A patient may be treated with Semaglutide indefinitely as long as the treating licensed medical professional approves of the continued use.
Semaglutide for weight loss dosage starts at .25 mg once a week for 4 weeks. Week 5 the dosage is increased to .50 mg for the next 4 weeks. At week 9 the dosage may be increased no more than .50 mg per week. The treating licensed medical professional may continue to increase the weekly dosage based on medication effectiveness, weight loss results, and tolerance to the medication. Dosage should not exceed more than 2.4 mg administered once per week. Semaglutide is self-administered by the patient using subcutaneous injections once a week.
Does Semaglutide need to be taken on an empty stomach?
The answer to this question depends on what form of Semaglutide the patient is taking. Semaglutide administered by subcutaneous injection can be taken with or without food once a week on the same day each week. Semaglutide administered orally in the form of a tablet such as the branded Rybelsus® is recommended to be taken without food on an empty stomach. Oral Semaglutide should be taken 30 minutes before the first meal of the day for the best results. There are no known foods that interact with Semaglutide in an oral form, but the amount of medication that is absorbed is reduced when food is present.
4. Combination and Interactions ↑
Can a diabetic take Semaglutide?
Yes. Semaglutide is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. This medicine is also used to lower the risk of heart attack, stroke, or death in patients with type 2 diabetes and heart or blood vessel disease. Semaglutide is not used to treat type 1 diabetes.
Can a non-diabetic take Semaglutide??
Yes. Semaglutide is an effective adjunct for weight loss in adults without diabetes who are overweight or obese.
What are the obesity criteria for Semaglutide?
Semaglutide may be administered subcutaneously,
once a week for adults with a Body Mass Index (BMI) of greater than 27 kg/m² with at least one weight-associated condition such as high blood pressure, type 2 diabetes (T2DM), or high cholesterol, or adults with a BMI of 30 kg/m² or greater.What medications should not be combined with Semaglutide?
Semaglutide should not be taken with other diabetes medication like
insulin and
sulfonylureas as it may lower blood sugar levels to dangerous degrees. Hypoglycemia is a rare side effect that can be induced if the patient is skipping meals or not properly maintaining their blood sugar after exercise.
Other medications that may affect the dosage or outcome of Semaglutide include
Chloroquine, Hydroxychloroquine, and Venlafaxine.
Nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and some herbal supplements should also not be taken.
The treating licensed medical professional will perform an extensive medical consultation which includes a review of all medications and supplements the patient is taking to help determine eligibility for Semaglutide.
Is a consistent dosage of Semaglutide required to see benefits from the medication?
Yes. Since Semaglutide is a hormone-based medication, it must be taken consistently over a long period of time for its benefits to be incorporated into the body. If a scheduled Semaglutide injection is missed for more than 2 days, the patient should take one as soon as possible. If the dose is less than 2 days away, the patient should skip the missed dose but make sure that the next scheduled injection is taken. Patients should consult the treating licensed medical professional if more than 2 weeks of doses are missed in order to restart the medication schedule.
What vitamins should be taken with Semaglutide?
Vitamin B12 is recommended when being treated with Semaglutide. Several research studies show that vitamin B12 aids in the treatment tolerance with GLP-1 medications.
Two of the most common adverse side effects of Semaglutide treatment are nausea and Hypophagia. Studies show
these reactions have been significantly reduced when Semaglutide is taken in conjunction with Vitamin B12.Should vitamin B12 be taken with Semaglutide and if so at what dosage?
Yes. Vitamin B12 is recommended when being treated with Semaglutide. Several research studies show that vitamin B12 aids in the treatment tolerance with GLP-1 agonists. Two of the most common adverse side effects of Semaglutide treatment are nausea and Hypophagia. Studies show these reactions have been significantly reduced when Semaglutide is taken in conjunction with Vitamin B12.
B12 may be administered as a subcutaneous injection once weekly. The dosage for vitamin B12 injections is typically .50 ml – 1.0 ml, 1 – 3 times per week. The treating licensed medical professional can determine if B12 injections are recommended and prescribe the appropriate dosage.5. Effectiveness and Results ↑
How are Semaglutide results maximized?
Weight loss results may vary from patient to patient using Semaglutide for weight loss. There are several steps a patient can follow to receive the maximum benefits of Semaglutide.
- Eat smaller portions of food more frequently.
- Concentrate on eating more slowly.
- Avoid any foods that may cause side effects.
- Drink plenty of water and extra water when exercising.
- Limit alcohol consumption to a minimum or refrain completely from alcohol.
- Strictly follow a diet plan and aim to lose a targeted amount of weight each week.
- Incorporate exercise into your weight loss program, particularly strength training if possible.
When can a patient expect to achieve weight loss results with Semaglutide?
Once the body gets used to Semaglutide, patients can expect weight loss results
within the first 4 weeks of taking the medication. Semaglutide should be used with an effective weight loss program that includes a low-calorie diet and physical exercise.
How quickly does Semaglutide work?
A patient may see results from Semaglutide in as little as 4 weeks. If a patient has already been going through an extensive weight loss program, he / she may see earlier results. Results will increase with time as the dosage increases. Typically, after one month's worth of Semaglutide medication results improve. Results continue to improve as the dosage is increased. Results vary from person to person depending on their overall health, medical conditions, lifestyle, age, gender, and other contributing factors.
Semaglutide medication has a titration period of 8 weeks which is enough time for the body to adjust to the actual amount required for weight management and subsequent weight loss. After week 8, dosage can increase .50 mg per week to as much as 2.4 mg per week. Even if a patient may not see weight loss results with a sufficient weight management regimen within the first 4 weeks, it's well expected as most studies show sufficient weight loss results after a period of higher dosage (2 mg - 2.4 mg) of Semaglutide injections.
The most important point for a patient taking Semaglutide is if he / she is tolerating the drug at a manageable level. Depending on the severity of the side effects and how it impacts his / her blood sugar level, the treating licensed medical professional may adjust the dosage for better results or tolerance.
What are the best ways to extend the effects of Semaglutide?
There are several external factors that a patient should consider in order to experience the most effective weight loss program while incorporating Semaglutide treatment.
- Follow the weight loss program.
The most effective path to weight loss while incorporating Semaglutide is strictly following a diet that maintains a low-calorie intake by avoiding foods high in fats and carbohydrates while providing the body with essential nutrients and protein.
- Exercise Regularly.
Strength training can help preserve and improve lean muscle mass which is essential for weight loss. Cardiovascular exercise can help burn additional calories, improve heart health, and improve overall health. The patient should discuss how to get started on a safe and effective exercise program with the treating physician.
- Make lasting lifestyle changes.
Making a commitment to permanent, better healthy lifestyle changes will improve the effectiveness of a weight loss program that incorporates Semaglutide treatment. Making better food choices, quantity of food consumed, quality of foods consumed, increased activity, better sleeping habits, and stress reduction are all factors that should be considered when trying to lose weight and maintain a healthy weight.
How does a patient know if Semaglutide treatments are working?
The patient's blood sugar will lower, food cravings will be reduced, and he / she will have a feeling of stomach fullness as the Semaglutide takes full effect. The patient's blood sugar levels should start to decline within the first week after the first dosage. The full effects of Semaglutide treatment can take 8 weeks or longer, as dosage is slowly increased. Semaglutide is a long-acting medication that is injected once weekly.
How much weight can a patient lose in a month with Semaglutide?
Patients receiving Semaglutide, 2.4 mg, lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28. No known retrospective studies have been conducted to assess the effectiveness of Semaglutide at the doses used to treat obesity.
What is the average A1C reduction with Semaglutide?
Studies suggest that larger proportion of patients significantly reached an A1C goal of less than 7% or less than 6.5% with Semaglutide in the low-dose comparison arms (p < 0.0001) and the high-dose comparison arms.
What are the limitations of Semaglutide?
Semaglutide should not be used with herbal or ayurvedic medicines. Semaglutide should not be used with any over-the-counter medication. Semaglutide should not be used in combination with other weight loss medications or products. Semaglutide should not be used by patients taking any other medications that produce adverse effects when combined with Semaglutide. Semaglutide should not be used by individuals under the age of 18 years. Semaglutide should not be used by people who have a history of Pancreatitis, Medullary Thyroid Cancer, Multiple Endocrine Neoplasia Syndrome Type 2 (MEN2), Diabetic Retinopathy, patients that have a medical history of severe depression.
How long does it take for Semaglutide treatments to suppress appetite?
Most patients using Semaglutide for weight loss can expect to see some results
in the first 4 weeks of usage with increased results within 12 weeks of starting treatment. The patient should always follow healthy eating habits and exercise 30 – 40 minutes a day, 3-4 days a week for maximum effectiveness when incorporating Semaglutide into a weight loss program.
6. Special Considerations ↑
What is the FDA criteria for Semaglutide?
Semaglutide (under the brand names Wegovy® and Rybelsus®) has been approved for weight loss by the FDA for patients that meet the following criteria.
The patient must be at least 18 years old with a body mass index (BMI) greater than or equal to 30 mg/kg² alone or 27 mg/kg² with at least one weight-related condition (e.g., high blood pressure, high cholesterol, Type 2 diabetes).What are the FDA guidelines for Semaglutide?
The FDA guidelines for Semaglutide injections for weight loss are a once weekly dosage, by subcutaneous injection on the same day each week, at any time of the day, with or without meals. The day of administration can be changed, if necessary, as long as the time between two doses is at least 2 days (48 hours). The maximum recommended dosage is 2.4 mg once weekly.
Is Semaglutide a miracle drug?
No. Semaglutide may seem like a miracle weight loss-inducing medication but it needs to be used properly under medical supervision with lifestyle intervention to fully work its effects. Semaglutide combined with a weight loss program and regular exercise have proven to be a very effective treatment protocol for obesity. There are many underlying factors that play a role in the effectiveness of Semaglutide treatment for weight loss which include, medical history, other medications, age, gender, activity level, lifestyle, stress, and sleep. Effectiveness may vary depending on these factors.
Why is Mounjaro (Tirzepatide) not covered by insurance?
Mounjaro (Tirzepatide) is
not yet approved as a weight loss medication, so insurance companies will not typically cover the cost of the medication even if a physician writes a prescription for weight loss (known as an "off-label" indication).
Does insurance pay for Semaglutide?
Not often. Semaglutide is a safe and effective treatment for type 2 diabetes and chronic weight management. However, Semaglutide is typically not covered for weight loss by most insurance companies.
Which weight loss medication is better Tirzepatide or Semaglutide?
Tirzepatide appears to be a more effective weight loss medication. In studies Tirzepatide sold under the brand name Mounjaro® reduced A1C by 2% to 2.3% compared to a 1.9% reduction for participants taking Semaglutide sold under the brand names Ozempic®, Wegovy®, and Rybelsus®. Tirzepatide led to weight loss of 7.7 kg (17 lb) to 11.4 kg (25 lb), on average, compared to 5.9 kg (13 lb) for Semaglutide.
Which weight loss medication is better Phentermine or Semaglutide?
Research shows that Phentermine appears to be a better short term weight loss medication while Semaglutide may be a more effective long term weight loss medication. Phentermine users in research studies saw an average of 5% weight reduction on a shorter-term weight loss program. Semaglutide users saw an average weight reduction of 6%-12% when the medication was used long term. Phentermine and Semaglutide are two different medications used to support weight loss in different ways. Phentermine is intended for short-term use while Semaglutide can be used for long term weight management. The treating licensed medical professional will conduct a consultation and help the patient determine what weight loss medication might be right for them.
When will FDA approve Mounjaro® (Tirzepatide) for weight loss?
Mounjaro® is expected to receive FDA approval for weight loss soon. The drug manufacturer of Mounjaro®, Lilly, plans to present its full study results at a conference in late June and will apply for FDA approval of a weight loss indication. Lilly expects an FDA decision soon after the full study has been presented.
7. Monitoring and Follow-up ↑
How often should I see the treating licensed medical professional while taking Semaglutide?
A patient will need to consult with the treating licensed medical professional once a month to review effectiveness, discuss any side effects, renew the prescription and make any dosage adjustments. The attending licensed medical professional may recommend additional follow up consultations if needed.
8. Prescription and Availability ↑
Can a physician or licensed medical professional prescribe Semaglutide for weight loss?
Yes. Semaglutide, which is sold under the brand names Ozempic®, and Wegovy® is administered as a subcutaneous injection that a physician or licensed medical professional may prescribe off-label for weight loss. Rybelsus® is an oral tablet branded Semaglutide also prescribed by physicians and licensed medical professionals for weight loss. Semaglutide can be extremely helpful for weight loss. Semaglutide belongs to a drug class called glucagon-like peptide-1 (GLP-1).
Does Semaglutide require a prescription?
Yes. Semaglutide is available only by prescription from a physician or licensed medical professional. Semaglutide is a glucagon-like peptide-1 (GLP-1). This medicine is also used together with diet and exercise to help lose weight and keep the weight off in patients with obesity caused by certain conditions.
What is the monthly cost of Semaglutide for weight loss?
Semaglutide sold under the brands Ozempic® and Wegovy® ranges from
$900 - $1500 for a 1-month supply. Because weight loss is not a label use, many insurance plans in the United States do not cover the cost of Semaglutide for weight loss. Compounded Semaglutide ranges from
$400 - $600 for a 1-month supply.
Can a physician or licensed medical professional prescribe Mounjaro® (Tirzepatide) for weight loss?
Yes. Mounjaro® is a branded name of Tirzepatide which is a medication that is administered by subcutaneous injection. A physician or licensed medical professional may prescribe Tirzepatide off-label for weight loss. Tirzepatide is not approved for this use yet but has proven effective as a weight loss medication.
9. Missed Dose and Management ↑
What happens when a patient stops taking Semaglutide?
Similar to other weight management medications, the weight lost during usage can be regained after treatment has been terminated. Patients should commit to permanent healthy lifestyle changes after treatment has been terminated to reduce the chances of regaining unwanted weight.
Can a patient skip a week of Semaglutide?
No. Semaglutide should be taken consistently to be effective. If a patient misses a dose, and the next scheduled dose is less than 2 days away, the patient should skip the missed dose and go back to the regular dosing schedule. If the patient misses a dose of Semaglutide for more than 2 weeks, the patient should take it on the next scheduled dose. The patient should contact the treating licensed medical professional about how to restart Semaglutide treatments.
10. Lifestyle and Recommendations ↑
Can a patient stay on Semaglutide for life?
Yes. Much like other diabetes medications, Semaglutide may be a long-term solution for some patients. Other patients may use medications like Semaglutide for a shorter period of time. The licensed medical professional treating the patient will determine the appropriate medications and duration in order to maximize effectiveness and overall patient health.
Can Semaglutide damage the pancreas?
Yes. Although rare, pancreatitis has been reported as a potential side effect of Semaglutide treatment. Pancreatitis is serious and can be life-threatening. The patient should seek immediate medical attention if he / she develops severe abdominal pain, experiences nausea, vomiting, and / or jaundice (yellowing of skin and eyes). Always contact the treating licensed medical professional if any symptoms or side effects occur.
What happens when you stop Semaglutide?
Typically, when a patient terminates Semaglutide treatment, the body fat and former appetite tend to return. Experts recommend committing to an improved long-term lifestyle plan. Semaglutide must be taken consistently to see long-term weight loss effects.
What foods should a patient avoid while being treated with Semaglutide for weight loss?
- Fried and greasy foods should be avoided. Many of the most common side effects of Semaglutide are gastrointestinal which include nausea, bloating, and gas as a result of eating these types of foods.
- Foods and beverages containing high amounts of sugar should be avoided.
- Foods high in refined carbohydrates such as pasta, white bread, white rice, and sweet desserts should be avoided.
- High-glycemic vegetables such as carrots, potatoes, parsnips, beetroots, and sweetcorn should be avoided.
- Alcohol should always be avoided and or kept to a minimum by anyone trying to lose weight.
Does a patient have to change his / her diet on Semaglutide?
Yes. A patient should follow his / her PWLC weight loss program while being treated with Semaglutide. If a patient is not eating a healthy diet, he / she may not feel well while being treated with Semaglutide. Eating healthier, while being treated with Semaglutide will reduce the risk of side effects, will increase the effectiveness of the weight loss program, and often increase the patient's energy levels.
What are the best foods to eat while being treated for weight loss with Semaglutide?
A patient being treated with Semaglutide should eat foods that
are light and bland and avoid foods that are fried, greasy, or overly sweet. Patients being treated with Semaglutide should
drink clear or ice-cold drinks like water or unsweetened tea.Will a patient regain unwanted weight when they stop taking Semaglutide?
Yes. Many patients do regain weight, but weight loss results can be retained with healthy lifestyle changes. When a patient stops being treated with Semaglutide food cravings will return and he / she will stop feeling full. Without lifestyle changes that include eating healthier, regular exercise, reduced stress, and quality sleep many patients are likely to regain unwanted weight.
Can too much Semaglutide be injected at one time?
Yes. A patient self-injecting Semaglutide should pay careful attention not to administer more than the prescribed dosage. A patient may develop severe hypoglycemia (low blood sugar) if too much Semaglutide is injected at one time. In the event of an overdose, the patient should seek immediate medical attention and monitor for signs and symptoms of low blood sugar using a glucometer. If any adverse symptoms occur the patient should contact emergency services as well as contact the treating licensed medical professional.
What are NICE guidelines for Semaglutide?
The National Institute for Health and Care Excellence (NICE) guidelines for using Semaglutide to treat weight loss
includes people with a BMI of 30 kg/m² or more (obesity), or a BMI from 27 kg/m² to less than 30 kg/m² (overweight) and at least 1 weight-related comorbidity.How many calories should a patient consume per day while being treated with Semaglutide for weight loss?
A patient's caloric
intake should not exceed more than 1,500 calories per day when being treated with Semaglutide for weight loss.
It is recommended that approximately 100 grams of protein per day be consumed by the patient. The patient should also try to exercise for 30-40 minutes a day 3-4 times a week for maximum weight loss and health benefits.
How much water should a patient being treated with Semaglutide drink?
A patient being treated with Semaglutide
should drink at least 64 ounces of water each day, which is 8 eight-ounce glasses. The patient may require additional water if they are exercising regularly or are an excessive sweater. It is very important that a patient being treated with Semaglutide drinks plenty of water to remain properly hydrated.
